Genetic conditions that increase ACC risk include: In about 50% of adrenocortical carcinoma cases, the disease runs in families. People with certain inherited genetic conditions have a higher risk of developing adrenal cancer. Who is at risk of getting adrenocortical carcinoma? Doctors diagnose only about one case per 1 million people each year. Nonfunctioning ACC tumor: This type of tumor doesn’t affect hormone production.Īdrenocortical carcinoma is very rare.Functioning ACC tumor: A functioning ACC tumor causes your adrenal gland to make more hormones than it normally should.These hormones control male and female traits and body functions such as blood pressure and response to stress.Īn adrenocortical carcinoma (ACC) is a cancerous adrenal tumor that forms in the adrenal cortex. The adrenal cortex makes hormones - including cortisol, testosterone, aldosterone and estrogen. There are two adrenal glands, one located at the top of each kidney. Adrenocortical carcinoma is cancer that forms in the outer layer (cortex) of the adrenal glands.
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